Which of the following are the salient features of the Double-helix structure of DNA? 1. The two chains have antiparallel polarity. 2. The bases in two strands are paired through hydrogen bonds (H-bonds) forming base pairs (bp). 3. The two chains are coiled in a right-handed fashion. Select the correct answer using the code given below.
Which of the following are the salient features of the Double-helix structure of DNA? 1. The two chains have antiparallel polarity. 2. The bases in two strands are paired through hydrogen bonds (H-bonds) forming base pairs (bp). 3. The two chains are coiled in a right-handed fashion. Select the correct answer using the code given below. Correct Answer 1, 2 and 3
The correct answer is 1, 2, and 3.
Key Points
The salient features of the Double-helix structure of DNA are as follows:
- It is made of two polynucleotide chains, where the backbone is constituted by sugar-phosphate, and the bases project inside.
- The two chains have antiparallel polarity. It means, if one chain has the polarity 5'à3', the other has 3'à5'. Hence statement 1 is correct.
- The bases in two strands are paired through hydrogen bonds (H-bonds) forming base pairs (bp). Hence statement 2 is correct.
- Adenine forms two hydrogen bonds with Thymine from the opposite strand and vice-versa.
- Similarly, Guanine is bonded with Cytosine with three H-bonds.
- As a result, always a purine comes opposite to a pyrimidine.
- This generates an approximately uniform distance between the two strands of the helix.
- The two chains are coiled in a right-handed fashion. Hence statement 3 is correct.
- The pitch of the helix is 3.4 nm (a nanometre is one-billionth of a metre, that is 10-9 m) and there is roughly 10 bp in each turn. Consequently, the distance between a bp in a helix is approximately 0.34 nm.
- The plane of one base pair stacks over the other in a double helix. This, in addition to H-bonds, confers the stability of the helical structure.
- The proposition of a double helix structure for DNA and its simplicity in explaining the genetic implication became revolutionary.
- Francis Crick proposed the Central dogma in molecular biology, which states that genetic information flows from DNA to RNA to Protein.
- In some viruses the flow of information is in the reverse direction, that is, from RNA to DNA.
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Feb 20, 2025