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Which of the following hormones does not bind to cell-surface receptors?

Which of the following hormones does not bind to cell-surface receptors? Correct Answer Testosterone

Concept-

  • Steroid hormones, such as testosterone, are hydrophobic molecules that diffuse freely into and act within all cells.
  • Therefore, there is no need for a receptor bound to the cell membrane, instead, there is a mobile receptor protein in the cytoplasm.

Key Points

  • Testosterone can easily cross cell membranes.
  • Cells do not need to invest in a trans-membrane delivery system if they can do the same for their intracellular receptors.
  • The signal gain may be lower (shorter signal steps mean fewer gain steps).
  • This means that the signalling pathway is less sensitive and/or slower, but is ideal for transmitting hormonal signals where transmission speed and specificity (in terms of precise location) are not very important.
  • It is intended to affect systems in the most cost-effective way at the right time.

Additional InformationTSH

  • TSH binds to the thyroid hormone (TR) receptor, a member of the nuclear hormone receptor family.
  • TR acts as a ligand-activated transcription factor that binds to the cognate thyroid hormone response element (TRE) in the promoter of the target gene.

PTH

  • The receptor binds to parathyroid hormone and belongs to the GPCR family of transmembrane proteins.
  • The parathyroid hormone 1 receptor (PTH1R) is a classical PTH receptor that is expressed at high levels in bone and kidney and modulates calcium ion homeostasis by activating adenylic acid cyclase and phospholipase C.

FSH

  • Follicle Stimulating Hormone (FSH), a glycoprotein hormone. , an essential component of the endocrine system that regulates gonad function and fertility.
  • FSH must bind to a receptor (FSHR) on Sertoli cells of the testis and granulosa cells of the ovary to transmit a signal.

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