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Erythema nodosum: An inflammatory reaction that occurs deep in the skin and is characterized by the presence of tender, red, raised lumps or nodules that range in size from 1 to 5 centimeters and are most commonly located over the shins but occasionally on the arms or other areas. The causes of erythema nodosum include medications (such as sulfa-related drugs, birth control pills, estrogens, iodides, and bromides), strep throat, cat scratch fever, fungal diseases, infectious mononucleosis, sarcoidosis, Behcet's syndrome, inflammatory bowel disease ( Crohn's disease and ulcerative colitis), and normal pregnancy. In many cases, no cause can be determined. Erythema nodosum may be self-limited. If treatment is needed, the underlying condition is treated, and treatment is simultaneously directed toward the erythema nodosum itself. Treatment can include anti-inflammatory drugs and cortisone given by mouth or injection. Colchicine is sometime used effectively to reduce inflammation.