What does Largactil IM Injection used for?

Largactil IM Injection contains Chlorpromazine Hydrochloride

Largactil IM Injection uses for

Chlorpromazine is indicated in Psychoses, Nausea and vomiting, Psychoses, Intractable hiccup, Psychoses.

Oral: Psychoses:

• Adult: 25 mg tid; may be given as a single 75 mg dose at night. Maintenance: 2500 mg tid increased to ≥1 g daily as required in psychotic patients.
• Child: 12 yr: 500 mcg/kg every 4 hr. Max: >5 yr: 75 mg daily; 1 yr: 40 mg daily.
• Elderly: Initially, ⅓-½ the normal adult dose.

Oral: Intractable hiccup:

• Adult: Initially, 250 mg 3 times daily for 2 days; if unresponsive, may admin 250 mg via IM inj. If still necessary, 250 mg in 500000 ml of normal saline may be given via slow IV infusion.
• Child: 12 yr: 500 mcg/kg every 4 hr. Max: >5 yr: 75 mg daily; 1 yr: 40 mg daily.
• Elderly: Initially, ⅓-½ the normal adult dose.

Intramuscular: Psychoses:

• Adult: 250 mg repeated every 6 hr. Substitute with oral therapy as soon as possible.
• Child: 12 yr: 500 mcg/kg every 4 hr. Max: >5 yr: 75 mg daily; 1 yr: 40 mg daily.
• Elderly: Initially, ⅓-½ the normal adult dose.

Intramuscular: Nausea and vomiting:

• Adult: Initially, 25 mg via IM inj, followed by 250 mg every 3 hr until vomiting stops.
• Child: 12 yr: 500 mcg/kg every 4 hr. Max: >5 yr: 75 mg daily; 1 yr: 40 mg daily.
• Elderly: Initially, ⅓-½ the normal adult dose.

May be taken with or without food. May be taken with meals to reduce GI discomfort.

Symptoms include somnolence, coma, hypotension and extrapyramidal symptoms. Other possible manifestations include agitation and restlessness, convulsions, fever, autonomic reactions such as dry mouth and ileus, EKG changes and cardiac arrhythmias. 

Treatment is symptomatic and supportive. Early gastric lavage may be helpful. Observe patient and maintain an open airway.

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