1 Answers
Kanaquine Injection contains Quinine Sulfate
Kanaquine Injection uses for
Quinine Sulfate, is an antimalarial drug indicated only for treatment of uncomplicated Plasmodium falciparum malaria. Quinine sulfate has been shown to be effective in geographical regions where resistance to chloroquine has been documented
Quinine Sulfate oral capsules are not approved for:
- Treatment of severe or complicated P. falciparum malaria.
- Prevention of malaria.
- Treatment or prevention of nocturnal leg cramps
Quinine Dihydrochloride is indicated for the acute treatment of malaria. It may also be used in the treatment of Babesiosis in conjunction with clindamycin.
Intravenous:
- Adult: Initially, 20 mg/kg to max 1.4 g over 4 hr with maintenance infusion started after 8 hr. Maintenance infusions: 10 mg/kg to max 700 mg over 4 hr 8 hrly. Loading dose should not be given if patient has received quinine, quinidine, halofantrine or mefloquine during the previous 24 hr.
- Child: ≤5 mg/kg/hr by slow IV infusion.
Oral:
- Adult: 648 mg given every 8 hr for 7 days.
- Child: ≥8 yr 10 mg/kg 8 hrly for 7 days.
Should be taken with food. Take with food to minimise GI discomfort.
Reconstitutions
Dilute in NaCl 0.9% to a concentration of diHCl 6000 mg/mL.
Symptoms: GI effects, CNS disturbances, oculotoxicity, cardiotoxicity,; tinnitus, abdominal pain, diarrhoea, vertigo, pulmonary oedema, hypotension, sweating, flushing, nausea, vomiting, headache, slightly disturbed vision, deafness, vasodilatation and adult resp distress syndrome.
Management: Administer multiple dose of activated charcoal within 1 hr or perform gastric lavage. Symptomatic (e.g. maintaining BP, respiration and renal function, treating arrhythmias) and supportive treatment.
Read more here Kanaquine