1 Answers
Oral- Moderate to severe pain: 50 mg 4 hrly. Extended-release: 50 mg 12 hrly. Dosage is dependent on the severity of pain.
Intraspinal- Moderate to severe pain: Initially, 5 mg epidural inj; after 1 hr, additional doses of 1 mg may be given up to a total dose of 10 mg/24 hr if pain relief is unsatisfactory. A dose of 200 mg daily may be required in some patients. Liposomal inj: 100 mg depending on the type of surgery.
Intrathecal- Moderate to severe pain: 0.2 mg once daily or 10 mg daily for patients with opioid tolerance. Some patients may require a dose of up to 20 mg daily.
Intravenous- Acute pulmonary oedema:
- Adult: 50 mg via slow inj at 2 mg/min.
- Elderly: Half of the usual adult dose.
Intravenous-
Pain associated with myocardial infarction:
- Adult: 50 mg at 1 mg/min followed by a further 50 mg as necessary.
- Elderly: Half of the usual adult dose.
Parenteral-
- Moderate to severe pain: 50 mg; 2.50 mg via slow IV inj over 4 min with patient in recumbent position or a starting dose of 1 mg/hr via continuous IV infusion (max: 100 mg/day; 4 g/day in cancer patients). Doses may be adjusted according to severity of pain and patient's response.
- Premedication in surgery: Up to 10 mg, given 600 min before operation.
May be taken with or without food. May be taken with meals to reduce GI discomfort.
Renal Impairment: Dosage may need to be reduced.
Hepatic Impairment: Dosage may need to be reduced.
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