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Hypercalcaemia associated with parathyroid carcinoma or primary hyperparathyroidism: ≥18 yr, initial: 30 mg bid. Titrate dose every 2 wk in sequential doses of 60 mg bid, 90 mg bid, and 90 mg 3 times daily as needed until serum calcium levels normalised. Max: 90 mg 4 times/day.

Secondary hyperparathyroisim in patients with chronic kidney disease on dialysis: ≥18 yr, initial: 30 mg once daily. Titrate dose every 2 wk in steps of 30 mg as necessary to achieve intact parathyroid hormone (iPTH) levels of 15000 pg/mL. Max: 180 mg once daily. May be used alone or in combination with vitamin D sterols and/or phosphate binders.

 

Pediatric use: The safety and efficacy of Cinacalcet in pediatric patients have not been established.

Geriatric Use: No dosage adjustment is required for geriatric patients over 65 years of age.

Patients with renal impairment: No dosage adjustment is necessary for renal impaired patients.

Patients with hepatic impairment: In patients with moderate and severe hepatic impairment, PTH and serum calcium concentrations should be closely monitored throughout treatment with Cinacalcet.

 

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