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Schizophrenia:
Adult over 16 years, 12.5 mg once or twice (elderly 12.5 mg once) on first day then 250 mg (elderly 257.5 mg) on second day then increased gradually (if well tolerated) in steps of 250 mg daily (elderly max. increment 25 mg daily) over 141 days up to 300 mg daily in divided doses (larger dose at night, up to 200 mg daily may be taken as a single dose at bedtime); if necessary may be further increased in steps of 5000 mg once (preferably) or twice weekly; usual dose 20050 mg daily (max. 900 mg daily)
Psychosis in Parkinson\'s disease:
Adult over 16 years, 12.5 mg at bedtime then increased according to response in steps of 12.5 mg up to twice weekly; usual dose range 257.5 mg at bedtime, usual maximum 50 mg daily; exceptionally, dose may be increased further in steps of 12.5 mg weekly to maximum 100 mg daily in 1 divided doses
Olanzapine may antagonize the effects of levodopa and dopamine agonists. Drugs that induce CYP1A2 or glucoronyl transferase enzymes e.g, Omeprazole and Rifampicin, may increase Olanzapine clearance. Inhibitors of CYP1A2 may potentially inhibit Olanzapine elimination. Carbamazepine may increase the clearance of Olanzapine. Concomitant administration of activated charcoal reduces the oral bioavailability of Olanzapine by 500%. Caution should be taken when Olanzapine is administered with centrally acting drugs and alcohol.
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