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Intravenous-

Acute leukaemias:

• Adult: 305 mg/m2 BSA daily on days 1 of the induction course and days 1 and 2 for the subsequent courses. Admin as a solution in 0.9% sodium chloride into a fast-running infusion of sodium chloride or glucose. May repeat course 3 wk later. Max (total cumulative dose): 550 mg/m2 in patients without risk factors for cardiotoxicity and 400 mg/m2 in patients who have received chest radiotherapy.
• Child: For acute lymphoblastic leukaemia: 25 mg/m2 BSA once wkly in combination with other regimens. <2 yr old or BSA <0.5 m2: 1 mg/kg once wkly. Max (total cumulative dose): 300 mg/m2 and in children <2 yr: 10 mg/kg.

AIDS-related Kaposi's sarcoma:

• Adult: As the liposomal formulation: Initially, 40 mg/m2 once every 2 wk, diluted in glucose 5% to a concentration of 0.2 mg/ml and given over 300 minutes. May continue for as long as disease control can be maintained.

Renal Impairment: Based on serum-creatinine concentrations: 10565 micromoles/l: 75% of the usual dose; >265 micromoles/l: 50% of the usual dose.

Hepatic Impairment: Based on serum bilirubin concentrations of 120 mcg/ml: 75% of the usual dose; >30 mcg/ml: 50% of the usual dose.

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