1 Answers

Intramuscular-

Diagnosis of iron storage disease:

  • Adult: 500 mg as a single dose. To estimate the excretion of Fe in urine over the next 6 hr. An excretion of >1 g suggests Fe storage disease and >1.5 g suggests a pathological cause.

Intravenous-

Aluminum overload:

  • Adult: Patients with end-stage renal failure, hemodialysis or hemofiltration patients: 5 mg/kg once a wk by slow infusion during the last hr of the dialysis session or 5 hr before the session in more severe cases. For patients on peritoneal dialysis: 5 mg/kg once a wk (via slow IV infusion/ SC/ IM/ intraperitoneally) should be given before the final exchange of the day.

Intravenous-

Diagnosis of aluminum overload:

  • Adult: 5 mg/kg given via slow IV during the last hr of the dialysis session. Increase in serum aluminium conc above baseline >150 ng/ml (measured at the start of the next dialysis session) suggests aluminium overload.

Parenteral-

Chronic iron overload:

  • Adult: Initially, 500 mg via IV/SC infusion (usually given over 82 hr or in some patients, 24 hr). Usual effective dose range: 200 mg/kg daily. Admin 3 times a wk depending on extent of iron overload. If given via IM inj, initial dose: 0.5 g daily as 1 or 2 injections; maintenance dose is determined by response.

Parenteral-

Acute iron poisoning:

  • Adult: Initial dose: 15 mg/kg/hr by slow IV infusion, reducing after 4 hr so that the total dose dose not exceed 80 mg/kg in 24 hr. It can also be given via IM Inj as a single dose of 2 g.
  • Child: Given via IM injection: 1 g as a single dose.

Intramuscular: Add 2 ml of sterile water for Inj to each 500 mg vial or 8 ml of sterile water for Inj to each 2 g vial.

Intravenous: Add 5 ml of sterile water for Inj to each 500 mg vial or 20 ml of sterile water for Inj to each 2 g vial. This results in a 10% solution. This can then be added to saline, glucose or Ringer's lactate solution to be used as an infusion.

 

 

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