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Intravenous- Reversal of benzodiazepine-induced sedation

• Adult: Anaesth: Initially, 200 mcg over 15 sec. A 2nd dose of 100 mcg can be given if desired degree of consciousness is not obtained w/in 60 sec. May be repeated at 60-sec intervals if necessary. Usual: 30000 mcg. Max: 1,000 mcg. Intensive care: Initially, 300 mcg over 15 sec. A repeat dose of 100 mcg may be administered if desired degree of consciousness is not obtained w/in 60 sec. May be repeated at 60-sec intervals if necessary. Max: 2,000 mcg. If drowsiness recurs, admin a 2nd bolus inj. Infusion of 10000 mcg/hr is also useful, adjust according to desired level of sedation.
• Child: >1 yr Initially, 10 mcg/kg (up to 200 mcg) over 15 sec. Repeat at 60-sec intervals if desired level of consciousness is not obtained after 45 sec. Max: 50 mcg/kg or 1,000 mcg, whichever is lower.

Intravenous-

Benzodiazepine overdose

• Adult: Initially, 200 mcg over 30 sec. Additional dose of 300 mcg may be given after 30 sec, followed by 500 mcg at 60-sec intervals if required. Max: 3,000 mcg or 5,000 mcg. Alternatively, infusion may be given at 10000 mcg/hr, adjusted according to response. Further doses may not be useful if a cumulative dose of up to 5,000 mcg does not produce any response. If symptoms of intoxication recur, may repeat doses at 20-min intervals; repeat doses should not exceed 1,000 mcg/dose (given as 500 mcg/min) and 3,000 mcg/hr.

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