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Initial dose: 1 mg orally twice a day
Titration: Increase in increments of not more than 2 mg twice daily as tolerated.
Target dose: 6 to 12 mg twice a day
Maximum dose: 24 mg/dayThis drug must be titrated slowly to avoid orthostatic hypotension; because of the need to titrate slowly, control of symptoms may be delayed during the first 1 to 2 weeks of treatment.
Renal Dose Adjustments: No adjustment recommended.
Liver Dose Adjustments-
- Mild hepatic impairment: No adjustment recommended.
- Moderate hepatic impairment: Use with caution.
- Severe hepatic impairment: Not recommended.
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