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Initial dose: 1 mg orally twice a day

Titration: Increase in increments of not more than 2 mg twice daily as tolerated.

Target dose: 6 to 12 mg twice a day

Maximum dose: 24 mg/dayThis drug must be titrated slowly to avoid orthostatic hypotension; because of the need to titrate slowly, control of symptoms may be delayed during the first 1 to 2 weeks of treatment.

 

Renal Dose Adjustments: No adjustment recommended.

Liver Dose Adjustments-

  • Mild hepatic impairment: No adjustment recommended.
  • Moderate hepatic impairment: Use with caution.
  • Severe hepatic impairment: Not recommended.

 

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