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The recommended dosage of Lapatinib for advanced or metastatic breast cancer is 1,250 mg (5 tablets) given orally once daily on Days 11 continuously in combination with capecitabine 2,000 mg/m2/day (administered orally in 2 doses approximately 12 hours apart) on Days 14 in a repeating 21 day cycle.
The recommended dose of Lapatinib for hormone receptor positive, HER2 positive metastatic breast cancer is 1500 mg (6 tablets) given orally once daily continuously in combination with letrozole. When Lapatinib is coadministered with letrozole, the recommended dose of letrozole is 2.5 mg once daily.
- Lapatinib should be taken at least one hour before or one hour after a meal. However, capecitabine should be taken with food or within 30 minutes after food.
- Lapatinib should be taken once daily. Do not divide daily doses of Lapatinib.
- Modify dose for cardiac and other toxicities, severe hepatic impairment, and CYP3A4 drug interactions.
Should be taken on an empty stomach. Take at least 1 hr before or 1 hr after a meal. Do not eat/drink grapefruit products.
Patient on potent CYP3A4 inhibitor-
- HER2 overexpressing advanced or metastatic breast cancer: Increase gradually from 1.25 g daily up to 4.5 g daily.
- HER2 overexpressing hormone receptor positive metastatic breast cancer: Increase gradually from 1.5 g daily up to 5.5 g daily.
Hepatic Impairment (Severe)-
- HER2 overexpressing advanced or metastatic breast cancer: 750 mg once daily.
- HER2 overexpressing hormone receptor positive metastatic breast cancer: 1 g once daily.
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