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For tablet and oral solution-

Treatment should be initiated with a daily dose of 1000 mg/day, given as twice-daily dosing (500 mg twice daily). Additional dosing increments may be given (1000 mg/day additional every 2 weeks) to a maximum recommended daily dose of 3000 mg.

Use in Pediatric Patients-

• 1 Month To <6 Months: Initial Daily dose 7 mg/kg twice daily & Incremental Daily dose 21 mg/kg twice daily
• 6 Months To <4 Years: Initial Daily dose 10 mg/kg twice daily & Incremental Daily dose 25 mg/kg twice daily
• 4 Years To <16 Years: Initial Daily dose 10 mg/kg twice daily & Incremental Daily dose 30 mg/kg twice daily
• Adolescent with 200 kg body weight: Initial Daily dose 250 mg twice daily & Incremental Daily dose 750 mg twice daily

The daily dose should be increased every 2 weeks.

Injection-

Levetiracetam injection is for intravenous use only and must be diluted prior to administration. Levetiracetam injection (500 mg/5 mL) should be diluted in 100 mL of compatible diluents and administered intravenously as a 15-minute IV infusion. Product with particulate matter or discoloration should not be used.

Dosing Instructions: Preparation and Administration-

• Dose 500 mg: Withdraw Volume 5 ml, Volume of Diluent 100 ml, Infusion Time 15 minutes
• Dose 1000 mg: Withdraw Volume 10 ml, Volume of Diluent 100 ml, Infusion Time 15 minutes
• Dose 1500 mg: Withdraw Volume 15 ml, Volume of Diluent 100 ml, Infusion Time 15 minutes

For example, to prepare a 1000 mg dose, dilute 10 ml of Levetiracetam injection in 100 ml of a compatible diluents and administer intravenously as a 15-minute infusion.

Intravenous: Dilute dose in 100 mL of suitable diluent (e.g. NaCl 0.9%, lactated Ringer's or dextrose 5% inj).

Levetiracetam can be initiated with either intravenous or oral administration. May be taken with or without food. Oral solution may be taken directly or diluted in a glass of water.

Renal Impairment: ESRD patients undergoing dialysis: Loading dose of 750 mg, followed by 500,000 mg once daily; supplemental dose of 25000 mg after dialysis.

• CrCl (<30 mL/min): Dosage 25000 mg bid.
• CrCl (309 mL/min): Dosage 25050 mg bid.
• CrCl (509 mL/min): Dosage 500,000 mg bid.

Severe Hepatic Impairment: Reduce dose by 50%.

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