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The patient should be placed on a standard cholesterol-lowering diet before receiving Lovastatin and should continue on this diet during treatment with Lovastatin . Lovastatin should be given with meals.
Adult Patients: The usual recommended starting dose is 20 mg once a day given with the evening meal. The recommended dosing range of Lovastatin is 100 mg/day in single or two divided doses; the maximum recommended dose is 80 mg/day. Doses should be individualized according to the recommended goal of therapy. Patients requiring reductions in LDLC of 20% or more to achieve their goal should be started on 20 mg/day of Lovastatin . A starting dose of 10 mg of Lovastatin may be considered for patients requiring smaller reductions. Adjustments should be made at intervals of 4 weeks or more. The 10 mg dosage is provided for information purposes only. Although Lovastatin tablets 10 mg are available in the marketplace, Lovastatin is no longer marketed in the 10 mg strength.
Cholesterol levels should be monitored periodically and consideration should be given to reducing the dosage of Lovastatin if cholesterol levels fall significantly below the targeted range.
Dosage in Patients taking Danazol, Diltiazem, Dronedarone or Verapamil: In patients taking danazol, diltiazem, dronedarone or verapamil concomitantly with Lovastatin , therapy should begin with 10 mg of Lovastatin and should not exceed 20 mg/day
Dosage in Patients taking Amiodarone: In patients taking amiodarone concomitantly with Lovastatin , the dose should not exceed 40 mg/day
Adolescent Patients (107 years of age) with Heterozygous Familial Hypercholesterolemia: The recommended dosing range of Lovastatin is 100 mg/day; the maximum recommended dose is 40 mg/day. Doses should be individualized according to the recommended goal of therapy. Patients requiring reductions in LDL-C of 20% or more to achieve their goal should be started on 20 mg/day of Lovastatin . A starting dose of 10 mg of Lovastatin may be considered for patients requiring smaller reductions. Adjustments should be made at intervals of 4 weeks or more.
Concomitant Lipid-Lowering Therapy: Lovastatin is effective alone or when used concomitantly with bile-acid sequestrants
Should be taken with food.
Dosage in Patients with Renal Insufficiency: In patients with severe renal insufficiency (CrCl< 30 mL/min), dosage increases above 20 mg/day should be carefully considered and, if deemed necessary, implemented cautiously.
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