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Oral-

• Palliative treatment of endometrial and renal carcinoma: 20000 mg daily.
• Mild to moderate endometriosis: 10 mg tid.
• Breast cancer: 0.4.5 g daily. Max: 2 g daily.
• Progestogen component in menopausal hormonal replacement therapy: Dosage dependant on oestrogen component of therapy, several regimens are used: 1.5 mg, 2.5 mg or 5 mg daily; 5 or 10 mg daily for 124 days of a 28-day cycle; 20 mg daily for 14 days of a 91-day cycle.
• Menorrhagia: 2.50 mg daily for 50 days starting on the 16th1st day of the menstrual cycle. Repeat for 2 cycles.
• Palliative treatment of prostatic carcinoma: 10000 mg daily.
• Secondary amenorrhoea: 2.50 mg daily for 50 days. Repeated for 3 cycles.

Intramuscular:

• Endometriosis: 50 mg wkly or 100 mg every 2 wk.
• Contraception: 150 mg every 12 wk.
• Palliative treatment of endometrial and renal carcinoma: Initially 0.4 g wkly. Reduce as necessary, maintenance may be as low as 0.4 g mthly.
• Palliative treatment of prostatic carcinoma: 0.5 g twice wkly for first 3 mth. Maintenance 0.5 g wkly.
• Breast cancer: 0.5 g daily for first 4 wk. Maintenance 0.5 g twice wkly.

Subcutaneous:

• Contraception, Endometriosis: 104 mg every 124 wk.

Pediatric Use: Medroxy Progesterone Acetate tablets are not indicated in children. Clinical studies have not been conducted in the pediatric population.

Geriatric Use: There have not been sufficient numbers of geriatric women involved in clinical studies utilizing Medroxy Progesterone Acetate alone to determine whether those over 65 years of age differ from younger subjects in their response to Medroxy Progesterone Acetate alone.

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