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Adults-

Tablets: Administer in divided doses 2 or 3 times daily, preferably 30 to 45 minutes before meals. Average dosage is 20 to 30 mg daily. Some patients may require 40 to 60 mg daily. In others, 10 to 15 mg daily will be adequate. Patients who are unable to sleep if medication is taken late in the day should take the last dose before 6 p.m.

Sustained release tablets: This tablets have a duration of action of approximately 8 hours. Therefore, Methylphenidate sustained release tablets may be used in place of Methylphenidate tablets when the 8-hour dosage of Methylphenidate sustained release tablets corresponds to the titrated 8 hour dosage of Methylphenidate. Methylphenidate sustained release tablets must be swallowed whole and never crushed or chewed.

Children (6 Years and Over)-

Methylphenidate should be initiated in small doses, with gradual weekly increments. Daily dosage above 60 mg is not recommended. If improvement is not observed after appropriate dosage adjustment over a 1-month period, the drug should be discontinued.

Tablets: Start with 5 mg twice daily (before breakfast and lunch) with gradual increments of 5 to 10 mg weekly.

Sustained release tablets: Methylphenidate sustained release tablet have a duration of action of approximately 8 hours. Therefore, Methylphenidate sustained release tablet may be used in place of Methylphenidate tablets when the 8 hour dosage of Methylphenidate sustained release tablet corresponds to the titrated 8 hour dosage of Methylphenidate. Methylphenidate sustained release tablet must be swallowed whole and never crushed or chewed.

If paradoxical aggravation of symptoms or other adverse effects occur, reduce dosage, or, if necessary, discontinue the drug. Methylphenidate should be periodically discontinued to assess the child's condition. Improvement may be sustained when the drug is either temporarily or permanently discontinued. Drug treatment should not and need not be indefinite and usually may be discontinued after puberty.

Should be taken on an empty stomach. Take 305 min before meals. May be taken with or without food.  Swallow whole, do not divide/chew/crush.

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