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Intravenous-Intubation of the small intestine, Premedication for radiologic examination of the upper gastrointestinal tract:

• Adult: 10 mg as a single dose by slow inj over 1 min.
• Child: <6 yr 0.1 mg/kg as a single dose; 64 yr 2.5 mg as a single dose.

Prophylaxis of chemotherapy-induced nausea and vomiting:

• Adult: For highly emetogenic drugs/regimens: Initially, 2 mg/kg by slow inj over at least 15 min, 30 min before chemotherapy. Repeat 2 hrly for 2 doses, then 3 hrly for 3 doses. For less emetogenic drugs/regimens: 1 mg/kg may be used. Max duration: 5 days.

Oral-

Nausea and vomiting associated with cancer chemotherapy or radiotherapy:

• Adult: 10 mg, up to tid. Max duration: 5 days.

Diabetic gastric stasis:

• Adult: 10 mg 4 times daily for 2 wk.

Gastro-oesophageal reflux disease:

• Adult: 105 mg 4 times daily, depending on severity of symptoms. If symptoms are intermittent, may give single doses of 20 mg prior to provoking situation. Max duration: 12 wk.
• Elderly: 5 mg/dose.

Parenteral-

Diabetic gastric stasis:

• Adult: 10 mg 4 times daily by IM inj or slow IV inj over 1 min for up to 10 days. Convert to oral admin when symptoms subside sufficiently.

Prophylaxis of postoperative nausea and vomiting:

• Adult: 10 mg as a single dose by IM or slow IV inj over at least 3 min.
• Child: 1 yr 104 kg: 1 mg tid; >3 yr 159 kg: 2 mg tid; >5 yr 209 kg: 2.5 mg tid; >98 yr 300 kg: 5 mg tid. Max duration: 48 hr.

Should be taken on an empty stomach. Take ½ hr before meals.

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