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Upper gastrointestinal haemorrhage:

• Adult: Intraperitoneal admin: 8 mg in 250 ml of 0.9% sodium chloride inj. Alternatively, instill 8 mg in 100 ml of 0.9% sodium chloride solution through a nasogastric tube every hr for 6–8 hr, then every 2 hr for 4–6 hr. Withdraw drug gradually.

Acute hypotensive states:

• Adult: Initially, 82 mcg/minute, up to 80 mcg/minute in refractory shock. Infuse using a solution of 4 mcg/ml in glucose 5%, or sodium chloride 0.9% and glucose 5% at a rate of 2 ml/minute. Adjust according to BP response. Average maintenance dose: 0.5 ml/minute (2 mcg/minute). Infuse via a central venous catheter or into a large vein.
• Child: Administer at a rate of 2 mcg/minute. Alternatively, 2 mcg/m2/minute. Adjust rate according to BP response and perfusion.
• Elderly: Initial dose should be at low end of dose range.

Intravenous: Dilute with 5% glucose inj, with or without sodium chloride; dilution with sodium chloride inj alone is not recommended.

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