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Recommended Dosing: The recommended starting dose of Pazopanib is 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). The dose of Pazopanib should not exceed 800 mg.

Do not crush tablets due to the potential for increased rate of absorption which may affect systemic exposure. If a dose is missed, it should not be taken if it is less than 12 hours until the next dose.

Dose Modification Guidelines:

• In advanced renal cell carcinoma, the initial dose reduction should be 400 mg, and additional dose decrease or increase should be in 200-mg steps based on individual tolerability.
• In advanced soft tissue sarcoma, a decrease or increase should be in 200-mg steps based on individual tolerability.

Hepatic Impairment

: No dose adjustment is required in patients with mild hepatic impairment. In patients with moderate hepatic impairment, alternatives to Pazopanib should be considered. If Pazopanib is used in patients with moderate hepatic impairment, the dose should be reduced to 200 mg per day. Pazopanib is not recommended in patients with severe hepatic impairment

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