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For intravenous infusion only. Do not administer as an intravenous push or bolus.
HER2 testing: Perform using FDA-approved tests by laboratories with demonstrated proficiency.
The initial Pertuzumab dose is 840 mg administered as a 60-minute intravenous infusion, followed every 3 weeks thereafter by 420 mg administered as a 30 to 60 minute intravenous infusion.
MBC: Administer Pertuzumab, trastuzumab, and docetaxel by intravenous infusion every 3 weeks.
Neoadjuvant: Administer Pertuzumab, trastuzumab, and chemotherapy by intravenous infusion preoperatively every 3 weeks for 3 to 6 cycles.
Adjuvant: Administer Pertuzumab, trastuzumab, and chemotherapy by intravenous infusion postoperatively every 3 weeks for a total of 1 year (up to 18 cycles).
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