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Saquinavir must be administered in combination with ritonavir.
Adults (over the age of 16 years): Saquinavir 1000 mg twice daily (5x200 mg capsules or 2x500 mg tablets) in combination with ritonavir 100 mg twice daily.
Saquinavir and ritonavir should be taken within 2 hours after a meal.
Pediatric Use: Pediatric dose recommendations that are both reliably effective and below thresholds of concern with respect to QT and PR prolongation could not be determined
Geriatric Use: Caution should be exercised due to greater frequency of decreased hepatic, renal or cardiac function in elderly population.
Impaired Renal Function: No initial dose adjustment is necessary for patients with renal impairment.
Impaired Hepatic Function: No dose adjustment is necessary for patients with mild or moderate hepatic impairment.
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