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The dosage of Sulfasalazine tablets should be individually adjusted according to the patient's tolerance and response to the treatment and taken in evenly divided doses preferably after meals.
Adult dose for crohn’s disease: 500 mg orally 2 to 4 times a day with food.
Pediatric use (6 years or older) for Ulcerative Colitis: The initial dose 40 to 60 mg/kg/day orally divided into 3 to 6 doses.
Adult dose for rheumatoid arthritis: 2 g daily in two evenly divided doses. It is advisable to initiate therapy with a lower dosage e.g. 0.5 to 1.0 g daily, to reduce possible gastrointestinal intolerance. A suggested dosing schedule is given bellow:
- First week: One tablet in the evening
- Second week: One tablet in the morning & One tablet in the evening
- Third week: One tablet in the morning & two tablet in the evening
- Forth week: Two tablet in the morning & two tablet in the evening
In case of rheumatoid arthritis 6 years or older: initial dose 10 mg/kg/day orally in 2 equally divided doses.
Juvenile rheumatoid arthritis-polyarticular course: Children 6 years of age and older: 30 to 50 mg/kg/day in two evenly divided doses. Typically the maximum dose is 2 g per day.
For other indications:
Initial therapy:
- Adults: 3 to 4 g daily in divided doses with dosage intervals not exceeding eight hours. It may be advisable to initiate therapy with a lower dosage e.g. 1 to 2 g daily to reduce possible gastrointestinal intolerance.
- Children 6 years of age and older: 40 to 60 mg/kg/day in to 3 to 6 divided doses.
Maintenance therapy:
- Adults: 2 g daily.
- Children 6 years of age and older: 30 mg/kg/day in 4 divided doses.
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