1 Answers

Parkinson's disease:

  • Adult: Initially, 100 mg/day, increased to 100 mg bid after a wk or more. Max dose: 400 mg daily.
  • Elderly: >65 yr: Lowest effective dose.

Prophylaxis of influenza A:

  • Adult: 100 mg daily for up to 6 wk; when used with influenza vaccination: only up to 3 wk after vaccination.
  • Child: 105 yr: 100 mg daily.

Influenza A:

  • Adult: 100 mg daily for 5 days.
  • Elderly: >65 yr: Daily dose of 1 day.

Herpes zoster in immunocompromised patients:

  • Adult: 100 mg bid for 14 days, continued for another 14 days if pain persists.

 

Patients with renal impairment:  The dose should be reduced. This can be achieved by either reducing the total daily dose, or by increasing the dosage interval in accordance with the creatinine clearance. For example:

  • CrCl <15 ml/min: Contraindicated
  • CrCl 155 ml/min: 100 mg every 2 to 3 days
  • CrCl >35 ml/min: 100mg every day

Patients with hepatic impairment: Use with caution

 

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