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Parkinson's disease:
- Adult: Initially, 100 mg/day, increased to 100 mg bid after a wk or more. Max dose: 400 mg daily.
- Elderly: >65 yr: Lowest effective dose.
Prophylaxis of influenza A:
- Adult: 100 mg daily for up to 6 wk; when used with influenza vaccination: only up to 3 wk after vaccination.
- Child: 105 yr: 100 mg daily.
Influenza A:
- Adult: 100 mg daily for 5 days.
- Elderly: >65 yr: Daily dose of 1 day.
Herpes zoster in immunocompromised patients:
- Adult: 100 mg bid for 14 days, continued for another 14 days if pain persists.
Patients with renal impairment: The dose should be reduced. This can be achieved by either reducing the total daily dose, or by increasing the dosage interval in accordance with the creatinine clearance. For example:
- CrCl <15 ml/min: Contraindicated
- CrCl 155 ml/min: 100 mg every 2 to 3 days
- CrCl >35 ml/min: 100mg every day
Patients with hepatic impairment: Use with caution
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