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Oral:Chronic bronchospasm:
- Adult: As hydrate: Initially, 22550 mg bid, increased if necessary.
- Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk.
Intravenous:Acute severe bronchospasm:
- Adult: Loading dose: 5 mg/kg (ideal body weight) or 25000 mg (25 mg/ml) by slow inj or infusion over 200 min. Maintenance infusion dose: 0.5 mg/kg/hr. Max rate: 25 mg/min.
- Child: Loading dose: same as adult dose. Maintenance dose: 6 mth yr: 1 mg/kg/hr and 106 yr: 0.8 mg/kg/hr.
- Elderly: Dose reduction may be necessary.
- Hepatic impairment: Dose reduction may be necessary.
Tablets should be swallowed whole and not chewed because of the structure of the tablet.
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