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Hodgkin's disease: 200 mcg/kg/day for 4 wk.

Non-Hodgkin's lymphoma: 10000 mcg/kg/day for 4 wk. Maintenance: Reduced daily dosage of intermittent courses of treatment.

Chronic lymphocytic leukaemia: Initially, 150 mcg/kg/day until the total leukocyte count falls to 10,000 microliter. Treatment may be resumed 4 wk after at a dose of 100 mcg/kg/day.

Waldenstrom's macroglobulinaemia: Starting dose of 62 mg daily until leucopenia occurs followed by 2 mg daily.

Should be taken on an empty stomach: Ensure adequate hydration. Swallow whole, do not chew/crush.

 

 

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