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Therapy should be initiated with the lowest possible dose and then titrated according to individual patient response. A single dose given in the morning with food is recommended; divided doses are unnecessary.
Edema: Up to 50 mg daily.
Hypertension: 25 mg daily in the morning, increased to 50 mg daily if necessary.
Heart failure: 250 mg daily in the morning, increased if necessary to 10000 mg daily (reduce to lowest effective dose for maintenance).
Maintenance doses may often be lower than initial doses and should be adjusted according to the individual patient.
Pediatric Use: Safety and effectiveness of Chlorthalidone tablets in pediatric patients have not been established.
Geriatric Use: Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.
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