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Previously untreated patients: 400 mg/m2 as single short term IV infusion over 150 min. Therapy should not be repeated until 4 wk after the previous course and/or until the neutrophil count is at least 2,000 cells/mm3 and the platelet count is at least 100,000 cells/mm3.
Patients previously treated with myelosuppresive therapy or patients with poor performance status: Reduce initial dosage by 205% (30020 mg/m2).
150 mg injection should be reconstituted with 15 ml of sodium chloride solution (0.9%) or water for injection.
450 mg injection should be reconstituted with 45 ml of sodium chloride solution (0.9%) or water for injection.
The reconstituted solution should be diluted by 300 ml (for 150 mg) & 900 ml (for 450 mg) of 5% glucose for injection or 0.9% sodium chloride solution for infusition.
Renal Impairment:
- CrCl (160 ml/min)- 200 mg/m2.
- CrCl (419 ml/min)- 250 mg/m2.
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