1 Answers
Intravenous (Adult)-
Small cell lung cancer: 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days. May repeat course at 3 wkly intervals after recovery from any toxicity. Inj must be diluted with 5% dextrose or normal saline to give a final concentration of 0.2.4 mg/ml and injected over 300 minutes. When given via oral capsules: the recommended dose is twice the IV dose rounded to the nearest 50 mg.
Testicular cancer: For combination therapy: 5000 mg/m2/day from days 1, or 100 mg/m2 on days 1, 3 and 5. May repeat course at 3 wkly intervals after recovery from any toxicity. Inj must be diluted with 5% dextrose or normal saline to give a final concentration of 0.2.4 mg/ml and injected over 300 minutes.
Oral (Adult)-
Small cell lung cancer: Twice the IV dose, rounded to the nearest 50 mg.
Renal impairment: CrCI: 150 ml/min- 75% of the recommended dose.
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