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Intramuscular-Acromegaly:
- Adult: Following initial control with SC therapy: As a depot preparation, initially 20 mg every 4 wk. Adjust if required after 3 mth to 100 mg every 4 wk. Max: 40 mg every 4 wk.
Intravenous-
Variceal haemorrhage in patients with cirrhosis:
- Adult: As continuous IV infusion: 25 mcg/hr for 48 hr (up to 5 days in patients at high risk of re-bleeding).
- Child: ≥1 mth: 1 mcg/kg/hr (up to 50 mcg/hr); given as continuous IV infusion. Higher doses may be needed initially, reduce dose gradually over 24 hr until bleeding has stopped.
Subcutaneous-
Prophylaxis of complications following pancreatic surgery:
- Adult: 100 mcg tid of a rapid-acting preparation given for 7 consecutive days, starting at least 1 hr before operation.
Subcutaneous-
Acromegaly:
- Adult: Initially 50 mcg tid, increased as necessary to usual dose 10000 mcg tid. Max: 500 mcg tid.
Subcutaneous-
Secretory neoplasms:
- Adult: Initially, 50 mcg 1 times daily, increased gradually to up to 600 mcg daily in 2 divided doses according to response. Continued treatment is not recommended if there is no benefit within a wk of starting treatment for carcinoid tumour. Initial dose may be given via IV admin of a rapid response is required.
Subcutaneous-
HIV-associated diarrhoea:
- Adult: Initial dose 100 mcg tid. If symptoms are not controlled after 1 wk, increase dose to 250 mcg tid, if still not effective after 1 wk stop therapy.
Renal Impairment: Dosage may need to be reduced in severe renal impairment requiring dialysis.
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