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For hereditary sideroblastic anemia: Initially, 20000 mg of vitamin B6 is used. The dose is decreased to 300 mg per day after an adequate response.
For vitamin B6 deficiency: In most adults, the typical dose is 2.55 mg daily for three weeks then 1.5.5 mg per day thereafter. In women taking birth control pills, the dose is 250 mg per day.
For abnormally high levels of homocysteine in the blood: For reducing high levels of homocysteine in the blood after childbirth, 5000 mg of vitamin B6 has been taken alone. Also, 100 mg of vitamin B6 has been taken in combination with 0.5 mg of folic acid.
For preventing macular degeneration: 50 mg of vitamin B6 in the form of pyridoxine has been used daily in combination with 1000 mcg of vitamin B12 (cyanocobalamin) 1000 mcg and 2500 mcg of folic acid for about 7 years.
For hardening of the arteries (atherosclerosis): A specific supplement (Kyolic, Total Heart Health, Formula 108, Wakunga) containing 250 mg of aged garlic extract, 100 mcg of vitamin B12, 300 mcg of folic acid, 12.5 mg of vitamin B6, and 100 mg of L-arginine daily for 12 months.
For kidney stones: 2500 mg of vitamin B6 has been used daily.
For nausea during pregnancy: 105 mg of vitamin B6 taken three or four times per day has been used. In people who don't respond to vitamin B6 alone, a combination product containing vitamin B6 and the drug doxylamine (Diclectin, Duchesnay Inc.) is used three or four times per day. Also, another product containing 75 mg of vitamin B6, 12 mcg of vitamin B12, 1 mg of folic acid, and 200 mg of calcium (PremesisRx, KV Pharmaceuticals) is used daily.
For symptoms of premenstrual syndrome (PMS): 5000 mg of vitamin B6 is used daily, alone or along with 200 mg of magnesium.
For treating tardive dyskinesia: 100 mg of vitamin B6 per day has been increased weekly up to 400 mg per day, given in two divided doses.

INJECTED INTO THE MUSCLE:

Hereditary sideroblastic anemia: 250 mg of vitamin B6 daily, reduced to 250 mg of vitamin B6 weekly once adequate response is achieved.

CHILDREN:

BY MOUTH:

For kidney stones: Up to 20 mg/kg daily in children aged 5 years and up.

INJECTED INTO THE VEIN OR MUSCLE:

For seizures that respond to vitamin B6 (pyridoxine-dependent seizures): 1000 mg is recommended.

The daily recommended dietary allowances (RDAs) of vitamin B6 are:

Infants 0 months, 0.1 mg
Infants 72 months, 0.3 mg
Children 1 years, 0.5 mg
Children 4 years, 0.6 mg
Children 93 years, 1 mg
Males 140 years, 1.3 mg
Males over 50 years, 1.7 mg
Females 148 years, 1.2 mg
Females 190 years, 1.3 mg
Females over 50 years, 1.5 mg
Pregnant women, 1.9 mg
Breast-feeding women, 2 mg
Some researchers think the RDA for women 190 years should be increased to 1.5.7 mg per day.

The recommended maximum daily intake is:

Children 1 years, 30 mg
Children 4 years, 40 mg
Children 93 years, 60 mg

Adults, pregnant and breast-feeding women:

148 years, 80 mg
over 18 years, 100 mg

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