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Schizophrenia:
- Adult: Initially, 20 mg bid, increase if necessary at intervals of not
- Elderly: Lower initial dose and slower titration.
Acute mixed or manic episodes in bipolar disorder:
- Adult: Initially, 40 mg bid, increased to 60 mg or 80 mg bid on the 2nd day. Adjust subsequent doses according to patient's response and tolerance level. Maintenance treatment of bipolar I disorder (adjunctive therapy to either lithium or valproate): Continue at the same dosage on which the patient was initially stabilised within 400 mg bid.
- Elderly: Lower initial dose and slower titration.
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