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Locally advanced disease has progressed during or following platinum-containing chemotherapy urothelial carcinoma (UC)

Locally Advanced Urothelial Carcinoma (UC) Progression during or following Platinum-Containing Chemotherapy: an Overview

Urothelial carcinoma (UC), also known as transitional cell carcinoma, is the most common type of bladder cancer and can also occur in other sections of the urinary tract. Locally advanced UC has progressed during or following platinum-containing chemotherapy in many cases, and thus poses a challenge for all types of cancer treatment. This article provides an overview of the current knowledge and treatment of locally advanced UC.

Current Knowledge of Locally Advanced UC

Locally advanced UC (LAUC) is defined as any form of UC that has progressed beyond the stage of superficial/low-risk disease, and but has not yet metastasized. LAUC often presents with larger and more aggressive tumors, and their presence in areas close to vital organs such as the kidneys can pose greater medical risks. Thus, the reviewing and treating of LAUC requires more caution and attentiveness.

The two most common therapeutic treatments for LAUC are radical radiotherapy and chemotherapy. Depending on the stage of the cancer, doctors may recommend a combination of both treatments. Surgery may also be an option for some cases of LAUC.

Role of Platinum-Containing Chemotherapy in Treating LAUC

Platinum-containing chemotherapy refers to the class of drugs that contain platinum compounds, such as cisplatin and carboplatin. These drugs are some of the most common and effective chemotherapy drugs used for LAUC and other types of cancer, and are also commonly referred to as “platinum agents.”

Platinum agents are generally given in combination with other drugs such as gemcitabine or paclitaxel, depending on the patient's stage and type of cancer. The combination of drugs can be especially effective at shrinking LAUC tumors and providing relief from symptoms. Additionally, platinum agents are relatively simple to administer, being typically given intravenously as an outpatient procedure.

Complications with Platinum-Containing Chemotherapy

Despite the effectiveness of platinum agents, they can also cause serious side effects such as nausea, vomiting, hair loss, increased risk of infections, and kidney damage. Additionally, LAUC cancer cells may become resistant to platinum agents over time, making them less effective in controlling the spread of the disease.

Additionally, patients should note that platinum agents are toxic and should be avoided during pregnancy and breastfeeding. Patients should inform their doctors of any allergies they may have to platinum compounds, as these can cause serious allergic reactions.

Conclusion

Locally advanced UC has the potential to progress during or following platinum-containing chemotherapy, presenting a challenge for both cancer patients and doctors. Platinum agents are some of the most common chemotherapy drugs for LAUC and can be highly effective with minimal side effects, but can also cause serious complications if not monitored properly. It is important for patients to talk to their doctor about the risks and benefits of using platinum agents, as they may provide an important part of their UC treatment plan.

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