DNA is a polymer of nucleotides which are linked to each other by 3’-5’ phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose? 

a. Replace purine with pyrimidines 

b. Remove/Replace 3' OH group in deoxy ribose 

c. Remove/Replace 2' OH group with some other group in deoxy ribose 

d. Both ‘B’ and ‘C’

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b. Remove/Replace 3' OH group in deoxy ribose

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