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Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.
Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents , small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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