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Gene therapy is being studied as a treatment for osteoarthritis. Unlike pharmacological treatments which are administered systemically, gene therapy aims to establish sustained, synthesis of gene products and tissue rehabilitation within the joint.
Osteoarthritis has a high degree of heritable factors, and there may be genetic risk factors for the disease. Gene transfer strategies for the potential medical management of osteoarthritis are under preliminary research to define pathological mechanisms and possible treatments for this chronic disease. Both viral and non-viral vectors have been developed as a means to carry therapeutic genes and inject them into human cells.
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