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In enzymology, a methylene-fatty-acyl-phospholipid synthase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are S-adenosyl methionine and phospholipid olefinic fatty acid, whereas its two products are S-adenosylhomocysteine and phospholipid methylene fatty acid.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase. This enzyme is also called unsaturated-phospholipid methyltransferase.

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