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In enzymology, a phosphoribosylformylglycinamidine synthase is an enzyme that catalyzes the chemical reaction
The 4 substrates of this enzyme are ATP, N2-formyl-N1-glycinamide, L-glutamine, and H2O, whereas its 4 products are ADP, phosphate, 2--N1-acetamidine, and L-glutamate.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is N2-formyl-N1-glycinamide:L-glutamine amido-ligase. Other names in common use include phosphoribosylformylglycinamidine synthetase, formylglycinamide ribonucloetide amidotransferase, phosphoribosylformylglycineamidine synthetase, FGAM synthetase, FGAR amidotransferase, 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase, , 2-N-formyl-1-N-glycinamide:L-glutamine, and amido-ligase.
It is known as ADE6 in Saccharomyces cerevisiae genetics.