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In enzymology, a CoA-disulfide reductase is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are CoA, NAD, and NADP, whereas its 4 products are CoA-disulfide, NADH, NADPH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CoA:NAD+ oxidoreductase. Other names in common use include CoA-disulfide reductase , NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase, CoADR, and coenzyme A disulfide reductase.
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