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In enzymology, an acetoacetyl-CoA reductase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are -3-hydroxyacyl-CoA and NADP, whereas its 3 products are 3-oxoacyl-CoA, NADPH, and H.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is -3-hydroxyacyl-CoA:NADP oxidoreductase. Other names in common use include acetoacetyl coenzyme A reductase, hydroxyacyl coenzyme-A dehydrogenase, NADP-linked acetoacetyl CoA reductase, NADPH:acetoacetyl-CoA reductase, D-beta-hydroxybutyryl CoA-NADP oxidoreductase, short chain beta-ketoacetyl-CoA reductase, beta-ketoacyl-CoA reductase, D-3-hydroxyacyl-CoA reductase, and -3-hydroxyacyl-CoA dehydrogenase. This enzyme participates in butanoate metabolism.