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In enzymology, a N-methyl nucleosidase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are 7-methylxanthosine and H2O, whereas its two products are 7-methylxanthine and D-ribose.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is 7-methylxanthosine ribohydrolase. Other names in common use include 7-methylxanthosine nucleosidase, N-MeNase, N-methyl nucleoside hydrolase, and methylpurine nucleosidase.

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