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In enzymology, a phosphatidylinositol deacylase is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are 1-phosphatidyl-D-myo-inositol and H2O, whereas its two products are 1-acylglycerophosphoinositol and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-phosphatidyl-D-myo-inositol 2-acylhydrolase. Other names in common use include phosphatidylinositol phospholipase A2, and phospholipase A2.

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