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Holocarboxylase synthetase ] ligase]], also known as protein—biotin ligase, is a family of enzymes. This enzyme is important for the effective use of biotin, a B vitamin found in foods such as liver, egg yolks, and milk. In many of the body's tissues, holocarboxylase synthetase activates other specific enzymes by attaching biotin to them. These carboxylases are involved in many critical cellular functions, including the production and breakdown of proteins, fats, and carbohydrates.
The catalyzed reaction:
The 3 substrates of this enzyme are ATP, biotin, and ]], whereas its 3 products are AMP, diphosphate, and propionyl-CoA:carbon-dioxide ligase.
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