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Mississippi wine refers to wine made from grapes grown in the U.S. state of Mississippi. The hot and humid climate of Mississippi makes it very difficult to cultivate vitis vinifera or French hybrid grapes. The three commercial wineries in Mississippi focus almost entirely on the Muscadine grape, a variety also used for non-alcoholic grape juices, jams, and jellies. Most of the Mississippi Delta AVA, a designated American Viticultural Area, lies within the state boundaries of Mississippi.

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