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Sumatriptan/naproxen, sold under the brand name Treximet among others, is a fixed-dose combination medication used to treat migraines. It is taken by mouth. It contains sumatriptan, as the succinate, a serotonin 5-hydroxytryptamine 1b/1d receptor agonist ; and naproxen as the sodium salt, a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs.

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