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Copper naproxen is a chemical complex of copper chelated with the anti-inflammatory drug naproxen. Copper complexes of NSAIDs like naproxen have been shown to have greater anti-inflammatory properties than the base drug.

Copper naproxen can by found as a monohydrate, and it can form complexes with other organic molecules such as nicotinyl alcohol, 3-methylpyridine, and caffeine.

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