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Signaling lymphocytic activation molecule is a family of genes. Homophilic binding between SLAMs is involved in cell-to-cell adhesion during antigen presentation.
Signaling lymphocytic activation molecules are a CD2-related surface receptor expressed by activated phagocytes, T helper cells, and platelets. SLAMs have a variety of functions, including enhancing T cellular proliferation by stimulating IL-4 and IFN-gamma production. SLAM family receptors can interact directly with microbes, which can cause phagocytic cells to migrate to the area. SLAMF activation can trigger SLAM-associated protein activation and a defective SAP can cause X-linked lymphoproliferative syndrome.
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