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Granulomatous–lymphocytic interstitial lung disease is a lung complication of common variable immunodeficiency disorders. It is seen in approximately 15% of patients with CVID. It has been defined histologically as the presence of granuloma and lymphoproliferation in the lung. However, as GLILD is often associated with other auto-immune features such as splenomegaly, adenopathy and cytopenias, a definition based on abnormalities on lung imaging together with evidence of granulomatous inflammation elsewhere has also been employed.
Although infections and complications of infection such as bronchiectasis are more common complications of CVID in the lung, the presence of immune manifestations including GLILD is important because this has been associated with greater risk of death.
In general, as a rare complication of a rare disease, the condition remains incompletely understood, and there is real need for further research in the area.