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Folate-binding protein are proteins that bind folate, typically the folate receptors and reduced folate carrier.
FBP can be a marker for ovarian cancer.
FBP can be measured to help in tumour classification to aid treatment, as it is over-expressed in more than 90% of ovarian and endometrial cancers, as well as 20-50% of breast, lung, colorectal, and renal cell carcinomas. FBP has very limited tissue distribution and expression in non-malignant tissue, making it a good immunotherapy target.
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